Аbstract: Urinary tract infections (UTIs) are common and affect men and women of all ages, vary
dramatically in their presentation and consequences, and are one of the most common reasons for
antibiotic prescriptions.
In 80-90%, the main causative agent is the uropathogenic Escherichia coli. (Foxman, 2014;
Flores-Mireles et al., 2015); also isolating Klebsiella pneumoniae (about 7%), Proteus mirabilis
(about 5%), Pseudomonas aeruginosa, Enterococcus faecalis, Enterobacter cloacae,
Streptococcus bovis and Candida albicans. (Parish and Holliday, 2012; Palou et al., 2013; Hof,
2017). Acute uncomplicated cystitis is an infection of the lower urinary tract occurring in the
absence of anatomical or functional abnormalities of the urinary tract or other complicating
factors. The purpose of this publication is to investigate and summarize: the effects of the herbal
preparation Bukonox in the treatment of acute uncomplicated cystitis and the need for immediate
antibiotic treatment. The object of the study are women with acute uncomplicated cystitis.
Questionnaire follow-up was conducted in 70 women with acute uncomplicated cystitis, divided
into 3 groups, according to the intake of medication in the treatment process:
-group A-takes an antibiotic as monotherapy.
-group B-takes Bukonox as monotherapy.
-group B- takes an antibiotic in combination with Bukonox.
Questionnaire follow-up of the 3 groups was carried out on day 3 and 5 of treatment, with each
patient evaluating the improvement of their symptoms compared to their baseline / on day 0 /
before the start of treatment / with points from 1 to 10.
On the 3rd and 5th day, the 3 groups of patients were monitored and assessed for the following
symptoms by questionnaire:
1. Pelvic pain.
2. Pain and burning when urinating.
3. Feeling of incomplete evacuation of urine from the bladder.
4. Frequent urges to urinate.
5. Painful feeling during intercourse.
These questions were derived from the ACSS, which is a questionnaire for self-reporting of
symptoms and severity in women with symptomatic lower urinary tract infections (LUTIs) and
their impact on quality of life (QL), as well as for differentiation from other urogenital diseases.
and the possibility of monitoring the effectiveness of the treatment. The results demonstrated high
efficacy and safety of the herbal preparation Bukonox in the treatment of acute uncomplicated
cystitis, both as monotherapy and in combination with an antibiotic. Bukonox is an effective and
safe alternative for the treatment of acute uncomplicated cystitis in women, which allows to reduce
the use of antibiotics. In our opinion, patients with complicated forms of urinary infection should
be treated with traditional antibiotic therapy, according to the result of uroculture and
antibiogram.

Keywords: antibiotics, urinary tract infections, uncomplicated cystitis, phytopreparations
antibiotic resistance

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