Summary: An increasing problem is the body's inability to absorb nutrients from the food 
and from traditional oral supplements, due to the lack of digestive efficiency of the 
contemporaneous population. Obesity-related vitamin D deficiency is probably due to 
reduced bioavailability of vitamin D3 from food (poor eating habits). Consequences of 
hypokinesia of the modern citizen are weight gain and reduced velocity of metabolic 
reactions. Some digestive dysfunctions can discontinue the appropriate absorption of food 
supplements, e.g. ulcers (Helicobacter pylori), gastritis, IBS, Chron's disease, 
malabsorption; consequences of endocrine dysfunction, obesity, hepatic problems, 
alcoholism, drug abuse (NSAIDs, antibiotics, laxatives, metformin), celiakia, conditions after 
bariatric surgery and etc. We observe an increasing deficit of key nutrients, result of extreme 
diets and sedentary lifestyle. The efficacy of drugs is not guaranteed, due to dramatically 
increasing malabsorption.
The aim of present work is to realize a systematic review on publications discussing the 
effectiveness oof oral spray formulas compared to traditional tablets and capsules.
We used clinical researches, published by collectives oof the Universities oof Cardiff and oof
Sheffield. The absorption of intra -oral spray forms is rapid (per buccal membrane or 
sublingually they penetrate directly to the bloodstream), Intra-oral spray forms do not pass 
through the digestive system. No interactions with other drugs or food. They are easy to 
apply - without water and without swallowing. Intra-oral spray technology has optimum 
bioavailability, quick intake, bypassing the primary processing by the gastrointestinal 
tract. These forms are more effective, fast and convenient alternative of tablets and 
capsules in the life of the modern citizen, in the context of increasing stress and aging 
population.
Keywords: intra-oral spray technology, vitamin deficiency, buccal absorption, digestive 
problems, obesity

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